Cochabamba
Cochabamba is a beautiful colonial city in the fertile Cochabamba valley nestled between the high Andes and the Chaparé cloud forest and Amazon. Cochabamba is famous for its cuisine, chicha, and fine year-round climate. Cochabamba is laid back, not very touristy, and strongly Quehcua and has the longest foreigner stay-time for these reasons.
Chuquisaca (Sucre)
Chuquisaca or Sucre is a delightful colonial city with a climate similar to that of Cochabamba. It sports many interesting sites to visit, chocolate industries, excellent universities, language schools and architecture. The Bolivian supreme court is based in Sucre and is considered a capital of Bolivia in name only, all other functions of government have resided in La Paz for the past 105 years.
La Paz - El Alto
La Paz and its sprawling neighbor El Alto combine to form Bolivia's largest city. Laz is built into a canyon-like valley and the city's steep streets and colonial architecture are a major draw for tourists. La Paz has fascinating markets and hosts most organs of the Bolivian government. El Alto is one of the world's fastest growing cities, once just a tiny highland suburb of La Paz.
Oruro
Is a mid-size highland mining center and serves as a jumping off point for trips to Uyuni and Chile. Oruro is famous for its annual Febraury Carnaval which combines indigenous and catholic traditions. The Oruro Carnaval is a UNESCO World Heritage event.
Potosí
Potosí was once the largest and wealthiest city in the entire world because it hosted the world's largest silver mine in the famous Cerro Rico. Potosí was the largest slavery project in human history and many miners still work in conditions little changed since pre-colonial times. Potosí is a treasure trove of colonial architecture, relics and makes a fascinating visit for history buffs and tourists alike.
Santa Cruz
Santa Cruz is Bolivia's second largest city after La Paz -El Alto and bears little similarity to the Andean capital. Santa Cruz is famous for its friendly hospitality and booming agri-business sector. From Santa Cruz visitors can reach the Amazon or the original Jesuit Missions and embark on a variety of jungle adventures.
Tarija
Tarija is a little-visited gem in Southern Bolivia. Capital of Bolivia's budding wine industry tourists with some extra time can visit bodegas and relax in Tarija's friendly small town atmosphere. The Spitting Llama recommends flying here as the overland journey is long and unpaved.
Trinidad
Trinidad is a buzzing Amazonian boom-town that sits right near the Mamoré river, a major tributary of the Amazon. Dirt bikes are the vehicle of choice in this exotic jungle hub and travelers can embark all manner of jungle and river journeys.